Prof. Dr. Ori Bar-Nur
Area of Interest
Regenerative and Movement Biology
Prerequisites a student should comply with
Interested students from D-HEST or D-BIOL with affinity for stem cell biology, molecular biology of skeletal muscle regeneration, disease modeling of skeletal muscle disorders and interest in utilizing genome editing tools and stem cell transplantation procedures to treat genetic diseases in mice models, or in human stem cell-based in vitro systems. Good background in molecular and cell biology is encouraged.
Recommended master courses (Electives) of Learning Agreement of the Major
376-0223-00 Advanced Topics in Exercise Pjysiology
376-0209-00 Molecular Disease Mechanisms
376-1392-00 Mechanobiology: Implications for Development, Regeneration and Tissue Engineering
551-0326-00 Cell Biology
636-0003-00 Biological Engineering and Biotechnology
376‐1614-00 Principles in Tissue Engineering
376‐1150-00 Clinical Challenges in Musculoskeletal Disorders
Research projects of the group
Our research group seeks to understand the principles that govern skeletal muscle regeneration, a key cellular process necessary for the repair of damaged muscle tissue due to injury or disease. To this end, we employ transgenic mouse models, stem cell culture techniques, genome editing and bioinformatic tools to delineate how muscle stem cells are generated, and elucidate their role in muscle regeneration and repair. Our long-term goal is to harness this mechanistic knowledge to develop stem cell-based therapeutic approaches to treat diseases involving degenerative loss of muscle mass. Research topics include:
- Molecular biology of skeletal muscle regeneration
- Stem cell biology with focus on muscle or pluripotent stem cells
- Disease modeling of skeletal muscle disorders
- Genome editing and stem cell transplantation procedures to treat muscle-related disorders