Dr. Collin Ewald

Dr. Collin Ewald
Lecturer at the Department of Health Sciences and Technology
ETH Zürich
Regenerat. Extrazellulärer Matrix
Additional information
Research area
Global Challenge: Age-dependent diseases
By 2030, almost every fourth person will be 65 or older in Switzerland, Europe, and the USA. Since old age is the main risk factor for developing cancer, neurodegenerative, cardiovascular, and metabolic diseases, as well as other age-related pathologies, the growing elderly population poses an immense social and financial challenge.
Strategic Goal: To identify novel strategies to improve human healthspan.
Using C. elegans is a pioneering system to model the aging process because of its ease of genetic manipulation, high evolutionary conservation of genes implicated in human diseases, and short lifespan (3 weeks). Importantly, using C. elegans lifespan assays as a read-out for extending healthspan is a tractable and fast approach for discovering novel mechanisms to confer healthy aging. Several fundamental mechanisms discovered in C. elegans have been shown to delay age-related pathologies in higher organisms, such as mice, and these mechanisms have major implications for human aging. Hence, by using C. elegans to model the aging process, we could rapidly identify strategies to improve human healthspan.
Research: Previously, the lab focused on exploring a novel and exciting mechanism that promotes healthy aging.
Our recent work has shown that many health- and longevity-promoting interventions re-activate the expression of extracellular matrix (ECM) genes during aging (Ewald et al., Nature 2015, PMID:25517099). This ECM enhancement is required and sufficient to extend the lifespan of C. elegans. Our research efforts focus on exploring the mechanism(s) of how prolonged ECM homeostasis promotes healthy aging.
CURRICULUM VITAE
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PERSONAL INFORMATION
Family name, First names: Ewald, Collin Yvès
Spoken languages: English (fluent), German (native), French (basic)
Nationality: Swiss
Current employer: Novartis Biomedical Research
ORCID: orcid.org/0000-0003-1166-4171, Research ID: K-6303-2015, Google Scholar, Wikipedia
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EDUCATION
2011 Ph.D. in Molecular Biology and Neuroscience, City University of New York, USA Ph.D. Supervisor: Chris Li
2008 Master of Philosophy, Biology, City University of New York, USA.
2007 Master of Science, Molecular Biology, University of Basel, Switzerland.
2005 Bachelor of Science, Molecular Biology, University of Basel, Switzerland.
2001 Matura in Mathematics, Gymnasium am Kirschgarten, Basel, Switzerland.
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CURRENT POSITIONS
2023- Associate Director of Diseases of Aging and Regenerative Medicine (DARe) at Novartis Biomedical Research
2023- Docent/Lecturer at ETH Zurich
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PREVIOUS POSITIONS
2023 Scientific Investigator and Professor at the University Department of Geriatric Medicine FELIX PLATTER
2016-2023 Assistant Professor (non-tenure track)
Institute of Translational Medicine/ Department of Health Sciences and Technology, ETH Zürich/ Switzerland.
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Led research team of 4 Ph.D. students and 3 postdocs, 1 Guest Professor, 17 Master Students / 2 Medical Students / 4 Bachelor Students / 3 High School Students.
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54 peer-reviewed publications from my independent lab (last 7 years), and 43 (co-)corresponding PI (and/or last author)
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1 patent granted
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Total 3rd Party funds raised (2016-2022): 3.5 million CHF
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Certified Good Clinical Practice GCP1-3, Animal experimentation license LTK1-2 (mice, rats), induced pluripotent stem cells (iPSC; DRC Harvard Medical School)
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10 Chair and 10 doctoral examinations (Ph.D. defenses)
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5 keynote talks, 30 invited talks at international conferences (including WEF)
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3 international and 4 national conferences co-organized
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>20 Interviews in newspapers, news media, and podcasts
2015 – 2016 Instructor in Medicine, Harvard Medical School, USA.
2015 – 2016 Visiting Scholar, Whitehead Institute for Biomedical Research (Massachusetts Institute of Technology), USA.
2015 – 2016 Research Associate, Junior Faculty Member, Joslin Diabetes Center, USA.
2011 – 2014 Postdoctoral Research Fellow in Medicine (with T. Keith Blackwell), Harvard Medical School, Joslin Diabetes Center, USA.
2006 – 2011 Graduate Research Fellow in Neuroscience (with Chris Li), City University of New York, USA.
2005 – 2006 Master’s research Friedrich Miescher Institute (FMI) for Biomedical Research (with Joy Alcedo and Nancy Hynes), University of Basel and part of the Novartis Research Foundation, Switzerland.
vertical_align_bottomCV PDFMembership
Since | Membership |
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2017 | Swiss Society for Aging Research |
2016 | Swiss Society for Matrix Biology |
Honours
Year | Distinction |
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2015 | Genetics Society of America (GSA) s DeLill Nasser Award for Professional Development in Genetics |
Additional information
Teuscher AC, Statzer C, Goyala A, Domenig SA, Schoen I, Hess M, Hofer AM, Fossati A, Vogel V, Goksel O, Aebersold R, Ewald CY. (2024) Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans
Nature Communications (IF2023 14.3) 15(1):276. doi: 10.1038/s41467-023-44409-2.
Molière A, Park JYC, Goyala A, Vayndorf EM, Zhang B, Hsiung KC, Jung Y, Kwon S, Statzer C, Meyer D, Nguyen R, Chadwick J, Thompson MA, Schumacher B, Lee SV, Essmann CL, MacArthur MR, Kaeberlein M, David D, Gems D, Ewald CY.
Geroscience (IF2023 5.3) 46(5):5015-5036. doi: 10.1007/s11357-024-01232-x. PMID: 38900346
Cyril Statzer, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Jin Meng, Krina Patel, Raffaella Emsley, Dunja Petrovic, Pengpeng Liu, Ianessa Morantte, Cole Haynes, Milos Filipovic, William B Mair, Alban Longchamp, T Keith Blackwell*, Collin Y Ewald* (2022)
ATF-4 and hydrogen sulfide signalling mediate longevity from inhibition of translation or mTORC1
Nature Communications (IF2021 17.7) 13(1):967. doi: 10.1038/s41467-022-28599-9 PMID: 35181679 *co-corresponding authors
Cyril Statzer, Elisabeth Jongsma, Sean X Liu, Alexander Dakhovnik, Franziska Wandrey, Pavlo Mozharovskyi, Fred Zuelli, Collin Y Ewald (2021)
Youthful and age-related matreotypes predict drugs promoting longevity
Aging Cell (IF2021 11.0) doi: 10.1111/acel.13441 PMID: 34346557
Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK. (2015). Dauer-independent insulin/IGF-1 signaling implicates collagen remodelling in longevity.
Nature (IF2015 38.1) 519, 97–101. doi: 10.1038/nature14021
Course Catalogue
Spring Semester 2025
Number | Unit |
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376-1667-00L | Drug Development: From Bench to Bedside |