Dr. Collin Ewald

Dr.  Collin Ewald

Dr. Collin Ewald

Lecturer at the Department of Health Sciences and Technology

ETH Zürich

Regenerat. Extrazellulärer Matrix

SLA C 8

Schorenstrasse 16

8603 Schwerzenbach

Switzerland

Additional information

Research area

Global Challenge: Age-dependent diseases

By 2030, almost every fourth person will be 65 or older in Switzerland, Europe, and the USA. Since old age is the main risk factor for developing cancer, neurodegenerative, cardiovascular, and metabolic diseases, as well as other age-related pathologies, the growing elderly population poses an immense social and financial challenge.

 

Strategic Goal: To identify novel strategies to improve human healthspan.

Using C. elegans is a pioneering system to model the aging process because of its ease of genetic manipulation, high evolutionary conservation of genes implicated in human diseases, and short lifespan (3 weeks). Importantly, using C. elegans lifespan assays as a read-out for extending healthspan is a tractable and fast approach for discovering novel mechanisms to confer healthy aging. Several fundamental mechanisms discovered in C. elegans have been shown to delay age-related pathologies in higher organisms, such as mice, and these mechanisms have major implications for human aging. Hence, by using C. elegans to model the aging process, we could rapidly identify strategies to improve human healthspan.

 

Research: Previously, the lab focused on exploring a novel and exciting mechanism that promotes healthy aging.

Our recent work has shown that many health- and longevity-promoting interventions re-activate the expression of extracellular matrix (ECM) genes during aging (Ewald et al., Nature 2015, PMID:25517099). This ECM enhancement is required and sufficient to extend the lifespan of C. elegans. Our research efforts focus on exploring the mechanism(s) of how prolonged ECM homeostasis promotes healthy aging.

CURRICULUM VITAE

 

  •  PERSONAL INFORMATION

Family name, First names: Ewald, Collin Yvès

Spoken languages: English (fluent), German (native), French (basic)

Nationality: Swiss

Current employer: Novartis Biomedical Research

ORCID: orcid.org/0000-0003-1166-4171, Research ID: K-6303-2015, Google Scholar, Wikipedia

 

  • EDUCATION

2011 Ph.D. in Molecular Biology and Neuroscience, City University of New York, USA Ph.D. Supervisor: Chris Li

2008 Master of Philosophy, Biology, City University of New York, USA.

2007 Master of Science, Molecular Biology, University of Basel, Switzerland.

2005 Bachelor of Science, Molecular Biology, University of Basel, Switzerland.

2001 Matura in Mathematics, Gymnasium am Kirschgarten, Basel, Switzerland.

 

  • CURRENT POSITIONS

2023- Associate Director of Diseases of Aging and Regenerative Medicine (DARe) at Novartis Biomedical Research

2023- Docent/Lecturer at ETH Zurich

 

  • PREVIOUS POSITIONS

2023 Scientific Investigator and Professor at the University Department of Geriatric Medicine FELIX PLATTER

2016-2023 Assistant Professor (non-tenure track)

Institute of Translational Medicine/ Department of Health Sciences and Technology, ETH Zürich/ Switzerland.

  • Led research team of 4 Ph.D. students and 3 postdocs, 1 Guest Professor, 17 Master Students / 2 Medical Students / 4 Bachelor Students / 3 High School Students.

  • 54 peer-reviewed publications from my independent lab (last 7 years), and 43 (co-)corresponding PI (and/or last author)

  • 1 patent granted

  • Total 3rd Party funds raised (2016-2022): 3.5 million CHF

  • Certified Good Clinical Practice GCP1-3, Animal experimentation license LTK1-2 (mice, rats), induced pluripotent stem cells (iPSC; DRC Harvard Medical School)

  • 10 Chair and 10 doctoral examinations (Ph.D. defenses)

  • 5 keynote talks, 30 invited talks at international conferences (including WEF)

  • 3 international and 4 national conferences co-organized

  • >20 Interviews in newspapers, news media, and podcasts

2015 – 2016 Instructor in Medicine, Harvard Medical School, USA.

2015 – 2016 Visiting Scholar, Whitehead Institute for Biomedical Research (Massachusetts Institute of Technology), USA.

2015 – 2016 Research Associate, Junior Faculty Member, Joslin Diabetes Center, USA.

2011 – 2014 Postdoctoral Research Fellow in Medicine (with T. Keith Blackwell), Harvard Medical School, Joslin Diabetes Center, USA. 

2006 – 2011 Graduate Research Fellow in Neuroscience (with Chris Li), City University of New York, USA.

2005 – 2006 Master’s research Friedrich Miescher Institute (FMI) for Biomedical Research (with Joy Alcedo and Nancy Hynes), University of Basel and part of the Novartis Research Foundation, Switzerland.

CV PDF

Membership

Honours

Year Distinction
2015 Genetics Society of America (GSA) s DeLill Nasser Award for Professional Development in Genetics

Additional information

Teuscher AC, Statzer C, Goyala A, Domenig SA, Schoen I, Hess M, Hofer AM, Fossati A, Vogel V, Goksel O, Aebersold R, Ewald CY. (2024) Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans

Nature Communications (IF2023 14.3) 15(1):276. doi: 10.1038/s41467-023-44409-2.

 

Molière A, Park JYC, Goyala A, Vayndorf EM, Zhang B, Hsiung KC, Jung Y, Kwon S, Statzer C, Meyer D, Nguyen R, Chadwick J, Thompson MA, Schumacher B, Lee SV, Essmann CL, MacArthur MR, Kaeberlein M, David D, Gems D, Ewald CY.

Geroscience (IF2023 5.3) 46(5):5015-5036. doi: 10.1007/s11357-024-01232-x. PMID: 38900346

 

Cyril Statzer, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Jin Meng, Krina Patel, Raffaella Emsley, Dunja Petrovic, Pengpeng Liu, Ianessa Morantte, Cole Haynes, Milos Filipovic, William B Mair, Alban Longchamp, T Keith Blackwell*, Collin Y Ewald* (2022)

ATF-4 and hydrogen sulfide signalling mediate longevity from inhibition of translation or mTORC1

Nature Communications (IF2021 17.7) 13(1):967. doi: 10.1038/s41467-022-28599-9 PMID: 35181679  *co-corresponding authors

 

Cyril Statzer, Elisabeth Jongsma, Sean X Liu, Alexander Dakhovnik, Franziska Wandrey, Pavlo Mozharovskyi, Fred Zuelli, Collin Y Ewald (2021)

Youthful and age-related matreotypes predict drugs promoting longevity

Aging Cell  (IF2021 11.0) doi: 10.1111/acel.13441 PMID: 34346557

 

Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK. (2015). Dauer-independent insulin/IGF-1 signaling implicates collagen remodelling in longevity. 

Nature (IF2015 38.1) 519, 97–101. doi: 10.1038/nature14021

 

Course Catalogue

Spring Semester 2025

Number Unit
376-1667-00L Drug Development: From Bench to Bedside